Error Cant Read File Or Presentation. You can unblock the file so it can be opened. As a quick workaround you can open a new presentation file copy all the slides from the presentation that wont save and then paste the slides in the new presentation.
Right click the PowerPoint file cant read. If your presentation file opens or works normally in safe mode then it looks like add-ins extensions or custom settings you made in PowerPoint are affecting the functionality of the application. Inserting slides from a corrupted PowerPoint file to a healthy presentation file.
Prime factors that could corrupt PowerPoint files are.
When PPT file shows errors and fails to open for reason unknown to you then it means that PPT file is broken or corrupted. Incorrect transfer of PPT PPTX files. Again you need to click on the File. Reset File Explorer Defaults.